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Accessed July 18, 2023

Surgical procedures or conditions that affect the gut, such as gastric bypass surgery or celiac disease, can prevent intrinsic factors from binding to B12 and prevent the body from breaking it down before absorbing the vitamin

Those with pre-existing conditions such as irritable bowel syndrome (IBS), functional dyspepsia, or gastritis may be more prone to experiencing stomach upset from supplements generally, including B12 preparations

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This sensation, called paresthesia, can result from nerve involvement related to a B12 deficiency, often in the hands, legs, or feet