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S.PauliouF.PerperopoulouF.GeorgakisN.Nianiou-ObeidatI.et al

Growth factors such as (e.g., VEGF, platelet-derived growth factor [PDGF] bind to a receptor tyrosine kinase (RTK) on the cell membrane, causing autophosphorylation of the receptor, thus creating docking sites for intracellular signaling proteins

In a dysregulated system, it tends to promote regulation

Modulation of transforming growth factor-beta (TGF-beta), integrins, and stem cell pathways have also been observed

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Diet, sleep, hydration, and sun protection all play a role