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In aged mice, FOXO4-DRI treatment restored fur density, improved renal function, and increased physical activity levels, demonstrating functional rejuvenation through targeted senescent cell clearance

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Cardiovascular Function Both IGF-1 and GH are partially responsible for cardiovascular system development and protection

Furthermore, its effects on damaged skin, muscle, tendon, and bone are comparable to those in the gastrointestinal tract (and liver, pancreas lesions) [1], kidney and cardiovascular system (particularly affecting blood vessels and vessel recruitment as part of therapy for heart failure and lung lesions, counteracting arrhythmias and thrombosis) [5,6]