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Perhaps the most profound challenge is assessing the long-term impact of such interventions on the already-formed tinnitus trace or maladaptive network within the central auditory system and associated limbic regions

J Phys Chem 117: 7843-7846

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No mixed disulfide intermediate was detected in accordance with a slow reaction between both proteins that was followed by a rapid intramolecular disulfide bond formation yielding roGFP2 WT (S 2 )