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The result is gas buildup in the upper GI tract that gets released as sulfur-scented burps, sometimes accompanied by a feeling of bloating, nausea, or general stomach discomfort that many people notice early in treatment
however, there are important caveats: - Injection-site reactions: As with any injectable peptide, mild redness, swelling, or irritation at the injection site appear to be the most commonly reported side effects
Clinical studies usually evaluate Retatrutide as a standalone therapy
Absolute contraindications include personal or family history of medullary thyroid carcinoma (MTC), Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), previous serious hypersensitivity to semaglutide or formulation components, pregnancy (the medication should be discontinued at least 2 months before planned conception), and breastfeeding due to insufficient data on excretion in human milk
In rodent studies, retatrutride has been shown to induce greater weight loss in obese mice compared to tirzepatide (8)
The trials target distinct populations: obesity or overweight without type 2 diabetes (TRIUMPH-1), with type 2 diabetes (TRIUMPH-2), severe obesity with established cardiovascular disease (TRIUMPH-3), and obesity with knee osteoarthritis (TRIUMPH-4)
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