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Two recent reviews make this clear

10.1016/j.neubiorev.2003.11.010 39 LautarS

However, these proteins were in circulation for only a short time, limited to 1-2 minutes, due to their degradation by the enzyme dipeptidyl peptidase-4 (DPP-4), which raised questions regarding use of GLP-1s as pharmaceutical treatments [9]

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