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Delivery of insulin directly to the CNS is possible through intranasal devices, which, in early trials, has been shown to improve cognition compared to placebo in AD patients [159]

Any use outside of formally approved clinical trials falls outside the regulatory framework that governs medicines safety in the UK, meaning that individuals who obtain and use retatrutide independently do so without the quality assurance, standardised dosing oversight, and pharmacovigilance protections afforded by licensed medicines

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Rosenmeier declares that she has received grant support from Merck Sharp & Dohme

Chen C, Kong AN