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Nat Rev Endocrinol 8:728742

19 The Endocrine Society's 2023 clinical practice guideline on obesity pharmacotherapy notes that "all GLP-1-based agents require individualized dose escalation schedules, and tolerability established on one agent cannot be assumed to transfer to another." 20 Special Populations: Who Tolerates Each Titration Best Patients with Prior GI Sensitivity For patients with a history of gastroparesis, irritable bowel syndrome, or prior GI intolerance on any GLP-1 agent, the slower retatrutide escalation offers a theoretical advantage

Hormonal imbalances, such as low testosterone or issues with the pituitary gland, also play a significant role

If it persists beyond eight weeks at stable dose or becomes severe enough to interfere with daily function, dose adjustment or medication switch is the solution

PMID: 2645190

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