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After binding to the GHR, the intracellular Janus kinase-2 (JAK2)-signal transducer and activator of transcription 5 (STAT5) and ERK1/2 pathways are activated [8]

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In biochemical and cellular research systems, ARA-290 interacts with the EPORCD131 receptor complex, initiating intracellular signalling cascades associated with cellular stress responses, inflammation modulation, and tissue protection

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