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Persons who have had a previous NTD-affected pregnancy or considered high-risk due to other factors (e.g., use of certain medications, family history) may be advised to consume up to 5,000 micrograms/day of folic acid when they are planning to become pregnant

doi: 10.1016/j.lfs.2005.05.103 46

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Kojic acid is something you apply to your skin to fade dark spots