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These events were tracked closely in trials because peptide-based medicines, including GLP-1 receptor agonists, have occasionally been linked to allergic responses ranging from mild skin irritation to more pronounced immune-mediated reactions

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Activation of the GLP- 1 receptor also prevents beta cell apoptosis

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According to him 'this was contrary to everything that was then believed about the physiological role of glucagon in glucose homeostasis if indeed there was one.' Just a couple of years before, Yalow and Berson had detected larger than normal rises in the plasma insulin levels in insulinoma patients injected with glucagon, but concluded this was due to insulin released from the liver