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In healthy conditions, the intestinal microbiota forms a symbiotic relationship with the host and interacts with epithelial cells and immune mucosal cells to maintain immune homeostasis through PRR-PAMP recognition [15, 45, 46]

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Eight-week old lean female mice were fed ad libitum with normal chow underwent SG or sham surgery

Gaucher's disease type 3, metachromatic leukodystrophy, Niemann-Pick disease type C, pantothenate kinase- associated neurodegeneration, Tay-Sachs disease and Wilson's disease