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Brian Hortz, PhD, AT just published a deep-dive on the mechanisms and why they matter

Clinical management aims to halt depigmentation, and to either repigment or depigment the skin, depending on the extent of disease

Research examining lasting neuroplastic changes rather than acute cognitive effects has successfully employed administration frequencies as low as three times weekly (every other day or Monday/Wednesday/Friday patterns) with outcomes comparable to daily dosing

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In addition, vitamin B12 affects homocysteine levels, which, at high levels, increases the risk of neurodegenerative diseases

Without adequate Vitamin C (and by extension, glutathione), the enzymatic reactions needed to form stable collagen triple-helix structures are impaired