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At these tiny doses, precision is everything

When utilizing sonication methods for preparing injectable solutions, it is important to consider factors such as type of solvent, temperature and duration of exposure, power intensity, sample concentration, and size distribution of particles in order to optimize the efficacy and safety of these drugs prior to administration

Summary of American Heart Association Diet and Lifestyle Recommendations revision 2006

Not being a medical professional, I would have like to see what 0.25 ml looks like in a 1 ml needle

doi:10.1111/j.1365-3164.2007.00647.x