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doi:10.1038/nrgastro.2015.150

GLP-1 receptor agonist medications like semaglutide (Ozempic and Wegovy) and tirzepatide (Mounjaro) work by mimicking this natural hormone, though at higher and more sustained levels than the body would produce on its own

[56] This biochemical cascade increases mitochondrial thermogenesis, effectively forcing the body to dissipate excess calories as heat and increasing overall energy expenditure