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Inhibition of NNMT has been explored in preclinical research for potential effects on adiposity regulation, insulin sensitivity, and metabolic efficiency

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Given that we have established selenoproteins such as GPx3 and SELENOP to be substantially reduced in those affected with disease using multiple applications and cohorts, perhaps a reduction in the ability to effectively manage oxidative damage is a leading factor for disease susceptibility and severity, when all other risk factors have been met, which are typically present even in those without konzo

Philp D, Huff T, Gho YS, Hannappel E, Kleinman HK

Blonna, D., Lee, G