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Heightened central affective response to visceral sensations of pain and discomfort in IBS

J Sci Med Sport 21(8):852857 Jones AM, Vanhatalo A, Seals DR, Rossman MJ, Piknova B, Jonvik KL (2020) Dietary nitrate and nitric oxide metabolism: mouth, circulation, skeletal muscle, and exercise performance

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The FDA-approved trials for tirzepatide included diverse populations, though specific post-cholecystectomy subgroup data remains limited

In a phase 2, randomized, double-blind, placebo-controlled trial (NCT04881760) involving adults with obesity without type 2 diabetes, retatrutide (1 mg12 mg weekly) produced dose-dependent weight loss of up to 24.2% from baseline at 48 weeks, compared with 2.1% with placebo

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