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Affecting 1 in 8 people globally , these disorders impair cognitive function, motor skills, and overall quality of life

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Setmelanotide was proven effective for weight loss in these genetically defined populations and is generally well tolerated 39

Once people stop taking weight-loss medications, the hunger-curbing effects of the drug are removed but their "food environment," such as ultra-processed foods, remains, and weight tends to return, said Dana Small, a professor at McGill University who holds a Canada Excellence Research Chair in metabolism and the brain

Limitations of This Comparison Several structural limitations constrain everything above, and honest readers should keep them in view: Species and model gap

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