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Dosing typically follows an escalation protocol, beginning at a low dose to improve tolerability before gradually increasing to a target maintenance dose over several weeks or months
Emerging 2025 research suggests semaglutide (the drug in Ozempic and Wegovy) is associated with lower RA disease activity, less pain, and improved joint outcomes especially in patients who also carry excess weight
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If nausea is severe, message your care team your doctor can hold the next dose increase or use a longer titration interval
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