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GLP-1 is synthesized and secreted from intestinal L-cells, and it is the prototype of a new class of blood glucose-lowering agents that are now in use for the treatment of type 2 diabetes mellitus (T2DM) 3

Substitution of GLP-1 regularizes the insulin release and prevents type-2 diabetes

However, people coming off weight loss injections typically experience increased hunger, as the appetite-suppressing effects of the drugs wear off

These are briefly reviewed below and in Figure 1

Semaglutide is a medication that mimics a hormone naturally occurring in the body, which regulates appetite and insulin secretion

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