(iii) the branched-chain -ketoacid dehydrogenase complex that is involved in the decarboxylation of ketoacids in the catabolic pathway of the branched-chain amino acids, namely leucine, isoleucine, and valine
In this mutant, several Ser/Thr/Cys residues in the sequence range of Ser74-Ser90 (SnCE1 C256A S74A/T76A/S77A/C81A/ S84A/S86A/S87A/S90A), in which we expect the autoproteolysis site to reside, were mutated to Ala and analyzed regarding its autoproteolysis
Considering the modulation of nerve cell function by the NO in vivo and in vitro studies, it has been shown that in all brain structures, NO modulates the release of several neurotransmitters
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Two of the five residues are D-configured