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It is unknown whether BYDUREON BCISE causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans, as the human relevance of exenatide extended-release-induced rodent thyroid C-cell tumors has not been determined [see Warnings and Precautions (5.1) and Nonclinical Toxicology (13.1)]

Letourneau et al., 2016

5c), the glutamate part interacts with S165 and D180, with a binding energy of 22.3 kcal/mol, while the cysteine part forms a hydrogen bond with E326

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