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Tirzepatide is a dual agonist, targeting the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, while retatrutide is a triple agonist, targeting GIP, GLP-1, and GCG simultaneously

The Phase 3 TRIUMPH-4 trial ran for 68 weeks with continued weight loss throughout, suggesting the plateau has not yet been reached at this timepoint (Lilly TRIUMPH-4 Press Release)

Temporary nausea, constipation, or mild digestive issues are common early on but usually improve with time

Most plateaus can be addressed through protocol adjustments rather than increasing your dose or switching medications

Three randomized trials have tested Eriomins effects on GLP-1 levels in people with prediabetes or type 2 diabetes

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