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While these medications had impactful weight loss outcomes, with mean weight reduction in trials ranging from 7 to 10% [3,4,5], they lacked substantial evidence of improvement in cardiovascular outcomes

Patients with type 2 diabetes receiving insulin or sulfonylureas alongside GLP-1-based therapies face a theoretical hypoglycaemia risk that clinicians should monitor

Sugars, sweet taste receptors, and brain responses

That means they arent tested for safety or effectiveness the way prescription medications are