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Western blot analysis was performed as described previously 9

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For example, ROS can facilitate the extrinsic apoptosis pathway through negative regulation of the cellular FLICE-inhibitory protein (Wang et al., 2008) and can induce intrinsic apoptosis pathways by triggering quick release of Cyt-c (Madesh and Hajnoczky, 2001) and regulating the Bcl-2 protein family (Burlacu, 2003)

117 Additionally, considered as a key antioxidative enzyme, NNT is critical for inducing macrophage inflammatory responses 118 and preventing ROS-induced cytotoxicity in T cells exposed to asbestos that can cause a reduction in antitumor immunity

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