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Conventional diagnostic pathways remain largely anchored in clinical guidelines, neuroimaging, and basic cognitive tests such as the Montreal Cognitive Assesment (MoCA), the Mini-Mental State Examination (MMSE) or disease-specific questionnaires like the Parkinsons Disease Questionnaire-39 (PDQ-39) (Folstein et al., 1975

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Methylmalonic acid (MMA): A more sensitive marker of B12 function