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Winfrey also addressed past criticism, noting that she once referred to prescription weight-loss medication as an 'easy way out.' In December 2023, after years of speculation, she publicly acknowledged using a GLP-1 drug and said she was 'done with the shaming' (seen in September 2025) 'I now use it as I feel I need it, as a tool to manage not yo-yoing,' she told People

doi: 10.1056/NEJMoa1515920 71 XuW

When it does, GLOW cannot provide that fourth research variable

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Rising popularity of GLP-1 therapies Obesity affects about 40 % of American adults

She dropped the weight by introducing exercise into her life but declared she would be chubby for life for four reasons: she has no hobbies except dieting, she has no discipline, men shes dated have been into me the way I am and shes pretty happy with the way I look, so long as I dont break a beach chair. Kalings new approach to wellness came after she navigated losing baby weight