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GLP-1 is a long-term commitment

Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury

Patients with a personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, severe gastroparesis, active pancreatitis, or who are pregnant or planning pregnancy are generally not candidates for GLP-1 therapy

Dose adjustments require provider review and approval - patients should never change dosing on their own

IV therapy is very safe when administered by licensed medical professionals

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