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QoL improved according to narrative reports, and the increases in FS, SCS, and RRM were significantly higher than the meaningful threshold, ranging from 2-fold (RRM 31-40) to 3-fold (FS 39-48) to 20-fold (SCS 27-36) above baseline ( Figure 3 )

The urea cycle is largely acyclical under physiological conditions in the brain, reducing the amount of nitrogen stress that is locally converted to urea

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