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Adults (aged 18 years) with a BMI 27 kg/m 2 and glycated hemoglobin (HbA 1c ) of 710% (5386 mmol/mol) were randomly assigned (1:1:1), to receive either once-weekly, subcutaneous tirzepatide (10 mg or 15 mg) or placebo for 72 weeks

However, because GLP-1 receptors exist in brain regions controlling mood, some individualsparticularly those with baseline mood vulnerabilitymay experience depressive symptoms

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Tirzepatide injections bypass your digestive system, so meal timing does not affect absorption or effectiveness