Lastly, although it has been shown that GABA is an HDACi in a neuroblastoma cell line (Xing et al., 2019), in our hands, GABA does not inhibit HDACs to a detectable level in colonic epithelial cells (unpublished)
Together, these findings highlight the functional link between GLR-mediated Ca 2+ /NO signalling and mitochondrial stress regulation in plants, suggesting that Arabidopsis can serve as a tractable system to explore conserved principles of mitochondrial dysfunction relevant to neurodegeneration
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Eva (36:06): Well, they're like, I survived nine 11