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NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimers disease

Recent findings indicate that organelles containing enzymes for the synthesis of O 2 - and H 2 O 2 can produce OH , which may damage DNA, leading to the development of oxidative DNA adducts

Given this finding we began examining Nle1- AngIV and found that as C-terminal amino acids were removed Ki decreased from 3.59 10-12 for Nle1-AngIV to 4.89 10-9 M for Nle1- tripeptide (Nle-Tyr-Ile)

A patient with an ATP5PO mutation encoding OSCP recently died from refractory status epilepticus, and a separate case involving a TMEM70 mutation also presented with status epilepticus (119)

Spectrophotometric and Colorimetric Kits Commercial glutathione assay kits are widely available and provide standardized protocols for laboratories that need reliable, reproducible results without extensive method development

Epub December 9, 2025