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In addition to monoaminergic systems, research suggests that BPC-157 may interact with inhibitory neurotransmission

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BPC-157 and Gabapentin Interaction: What You Need to Know At a glance BPC-157 status / 503A compounded research peptide, not FDA-approved Gabapentin class / alpha-2-delta calcium channel ligand, anticonvulsant Formal interaction studies / none published as of 2025 Primary concern / additive CNS depression (sedation, dizziness) Secondary concern / both agents rely heavily on renal elimination CYP450 involvement / gabapentin: none