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In the landmark study that introduced it, published in Cell Metabolism (Lee et al., 2015), researchers showed that MOTS-c regulates insulin sensitivity and metabolic homeostasis through the AMPK pathway, and that treatment prevented diet-induced obesity and insulin resistance in animal models

Drug-induced thyroid disorders

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68 vs 72 weeks in T2D STEP-2 also showed 1.6% HbA1c improvement at 68 weeks

Bone Mineralisation: Studies examining the effect of pulsatile GH release on osteoblast function and bone density in animal models