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What the Evidence Shows and What It Does Not MedicalDaily Evidence Check Study type: Phase 2b randomized clinical trial Participants: 272 adults with type 2 diabetes, average age 50.8, from 37 sites in China Published in: Annals of Internal Medicine , June 30, 2026 (DOI: 10.7326/ANNALS-25-04623) What it found: Biweekly bofanglutide produced HbA1c reductions and weight loss comparable to weekly semaglutide in Chinese patients with type 2 diabetes What it did not prove: The trial was not conducted in U.S
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Phase 3 Retatrutide data from the TRIUMPH program are expected to refine these estimates
A separate Phase 3 trial called ATTAIN-MAINTAIN, also disclosed in the Q4 deck, showed that patients switching from injectable semaglutide or tirzepatide to oral orforglipron maintained their weight loss over 52 weeks of extension
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