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In cancer settings, acetyl-L-carnitine increased chemotherapy-induced peripheral neuropathy (CIPN) (35) , which persisted at the 2-year follow-up (53)

In obese subjects, overpopulated immune cells (mainly macrophages) and dysfunctional adipocytes secrete a variety of cytokines and chemokines, causing low-grade long-term inflammation in AT, which plays a determining role in metabolic diseases, such as cardiovascular diseases, liver steatosis and type 2 diabetes [2]

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Pain at the injection site represents a recognized local adverse reaction that occurs through several mechanisms