One commenter highlighted the potential for disproportionate impact on small, rural, and safety-net hospitals and encouraged CMS to monitor these effects during implementation
He says injecting drugs became "normalized" when GLP-1 drugs approved to treat diabetes, such as Ozempic, were also shown to be effective for weight loss and eventually became an approved treatment for obesity
Furthermore, the Safety of Care RFI included in the CY 2025 OPPS/ASC Proposed Rule (89 FR 94514 through 94521) provided the public with information about potential methodology updates that were being considered by CMS
Rare side effects Increased appetite: Paradoxical for a fat loss peptide, but some users report increased hunger
PubMed PMID 41476424, 2026
Adults (19-64 years) are usually recommended to consume about 1.5 micrograms a day or more if they are not getting sufficient B12 from their diets