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ICH Q2(R2) also notes that representative data such as chromatograms can help demonstrate specificity for assay, purity, or impurity tests [13]

74 Notably, the upregulation of ZEB1 inhibited expression of the gemcitabine transporter via ITGA3/ITGB1/31 signaling and c- JNK pathway, which leads to chemoresistance both in vitro and in vivo

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