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Repurposing monoamine oxidase inhibitors (MAOI) for the treatment of rheumatoid arthritis possibly through modulating reactive oxidative stress mediated inflammatory cytokines

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To date, therapies to treat intervertebral disc degeneration are limited, involving broad-spec anti-inflammatory drugs, which have undesirable side effects, or surgeries that are invasive, risky, and require long recovery times

The mRNA levels of key genes in these pathways, such as Sqle, Dhcr7, Cyp51, Shc2, Hspa1a , and Hspa1l , were significantly different between EGCG-treated mice and HFHC mice as well (Figures 8F,G)

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