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Despite the good initial efficacy of the oral antihyperglycemic agents, patients with T2DM often require multiple antihyperglycemic agents to achieve glycemic control because of the progressive nature of diabetes mellitus [219]

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Other factors which may increase the risk of hypoglycemia include changes in meal pattern (e.g., macronutrient content or timing of meals), changes in level of physical activity, or changes to co-administered medication [see Drug Interactions (7)]

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Who Can Receive Weight Loss Medications Candidates for these medications typically have a BMI of 30 or more or a BMI of 27 with related health issues