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Via once-weekly subcutaneous injection

Once-weekly semaglutide produced sustained, clinically meaningful weight loss in people with obesity. (Wilding, New England Journal of Medicine )

In the STEP 4 trial, participants who achieved significant weight loss on semaglutide 2.4 mg were randomized to either continue the medication or switch to placebo

Clinical trial results (SURMOUNT trials): Average weight loss: 20-22% of body weight At 72 weeks on 15mg dose: 48 pounds for a 200-pound person 91% of participants lost at least 5% body weight 63% lost at least 20% body weight This is the most effective weight loss medication ever tested

A BMI of 30 or higher is considered obesity, while a BMI of 27 to 30 is considered overweight

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