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Retinoic acid is an important bioactive derivative of lipophilic vitamin A, and the alteration of retinoic acid signaling may participate in the pathogenesis and pathophysiology of PD

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FOXO4-DRI improves spermatogenesis in aged mice through reducing SASP secretion from Leydig cells

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These include ferroptosis suppressor protein 1(FSP1)/CoQ10, GTP cyclohydrolase1 (GCH1)/tetrahydrobiopterin (BH4), and dihydroorotate dehydrogenase (DHODH) ( Figure 1 )