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The binding of the RGD motifs to the V integrins expressed in tumor endothelial cells induces the protease-mediated cleavage of the iRGD peptide, producing two peptides, namely, CRGDR/K and GPDC

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It has been shown that the synthesis of cysteinyl leukotriens is impaired in patients with glutathione synthetase deficiency [25]

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