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Although 5% weight loss did not show a net benefit, Moll and colleagues noted that it could be net beneficial for some individuals, depending on their willingness to accept the harm outcomes. For example, one of the harm outcomes that highly influenced the unfavorable benefit-harm balance of tirzepatide was alopecia, they explained

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The company is investigating tirzepatide in patients with overweight and obesity who do not have type 2 diabetes, with Mounjaro poised to add the hot indication of chronic weight management to its label by the end of this year

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