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(8) Research has documented that IGF-1 signaling plays important roles in insulin sensitivity and substrate metabolism, and IGF-DES provides a tool for studying these effects independent of IGFBP modulation
[3] In REDEFINE 2 , a parallel 68-week Phase 3a trial in 1,206 adults who had overweight or obesity and type 2 diabetes, once-weekly CagriSema produced an estimated mean weight change of 13.7% versus 3.4% with placebo, alongside marked improvements in glycemic control
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Unlike oral supplements, this combination ensures complete bioavailability, making it ideal for patients with MTHFR gene mutations affecting B vitamin metabolism
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