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PI3K/AKT activate STAT3 signaling The PI3K/AKT axis, downstream from the InsR/IGF-1R complex, has several upstream and downstream signaling connections (Fig

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In another model, the human neuroblastoma SH-SY5Y, it is possible to observe a huge difference in MOR desensitization produced by morphine and remifentanil on the cAMP pathway but not on the MAP kinases ERK1/2 (Nowoczyn et al., 2013)