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The short-acting GLP-1 receptor agonists primarily lower postprandial blood glucose levels through inhibition of gastric emptying, whereas the long-acting compounds have a stronger effect on fasting glucose levels, which is mediated predominantly through their insulinotropic and glucagonostatic actions

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TD Cowen analyst Steve Scala has flagged the high rate of discontinuation as a concern and suggested it could make outcomes of future trials harder to predict