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The hair-growth interest comes from a line of animal research: T4 was shown to increase hair growth in rats and mice by activating hair-follicle stem cells in the bulge region, per PubMed (Philp et al., 2003, DOI), with follow-up work showing faster regrowth in T4-overexpressing mice and slower regrowth in knockout mice via VEGF and P38/ERK/AKT signalling (Gao et al., 2015, DOI)

Accordingly, it is reported that glutamate supplementation of up to 1-2 mM enhanced IFNy and IL-10 secretion by activated adult human peripheral T cells in vitro , whereas secretion of T H 2 cytokines IL-4 and IL-5 was unaffected (180)

A SLC39A8 (ZIP8 A391T) variant identified in genome-wide studies disrupts the regulation of multiple metals, including Mn, and increases susceptibility to Crohns disease (Li et al., 2016)

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Additionally, the MR-PRESSO test did not identify any outlier SNPs in our analysis, indicating that there is no pleiotropy