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In fact, NRF2 deletion causes an increase in OS and cellular death both in vitro and in vivo [137, 138]

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There is evidence that VGEF can be particularly involved in schizophrenia [291,292,293,294], given abnormal vascularization and VEGF acting as an angiogenic and neurotrophic factor involved in the regulation of cerebral blood volume and flow in schizophrenia [294]