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Sci Transl Med (2016) 8(370):370ra180

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Our findings delineate a novel mechanism of communication from mitochondria to the ER, reveal an unexpected protective role for GSSG, and provide a plausible pathway by which ER homeostasis is linked to metabolic activity

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Environmental Factors: Exposure to environmental toxins, pollution, and certain lifestyle factors, such as smoking and alcohol consumption, can contribute to the depletion of glutathione levels in the body

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Furthermore, the literature also focused on the succinylcholine-induced neuromuscular junction blockade [102], local anesthesia [103,104] (i.e., via lidocaine intraplantar application and axillary and spinal (L4-L5) intrathecal block [103]), electrolytes disturbances [19,55,80,105,106], neuroleptics dopamine blockade [26,51,54,55], NO-system blockade [26], alcohol intoxication [22], serotonin syndrome [25], particular neurotoxins (inducing Parkinson-like disturbances in mice [30] or multiple sclerosis-like disturbances in rats [31]), and tumor cachexia [10]

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